The Greek Septuagint does originate from Alexandria where the family of Philo was among the most prominent. I suppose if Philo's family did descend from the Jerusalem High Priests (and the pharaohs before that) then they would have been one of the first to be consulted for the Septuagint project. If this family was also associated with Ptolemy and Nicolaus of Herod the Great's administration, then they were certainly also prominent in Syria, especially Damascus and perhaps also Abilene ("Abel"), a locale between Chalcis and Damascus.
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